Current Issue : April-June Volume : 2010 Issue Number : 2 Articles : 4 Articles
Floating drug delivery is associated with certain limitations. Drugs that irritate the mucosa, those that have multiple absorption sites in the gastrointestinal tract, and those that are not stable at gastric pH are not suitable candidates to be formulated as floating dosage forms. To overcome this limitation, a bioadhesive polymer can be used to coat the dosage so that it adheres to gastric mucosa, or the dosage form can be administered with a full glass of water to provide the initial fluid for buoyancy. Single unit floating capsules or tablets are associated with an “all or none concept,” but this can be overcome by formulating multiple unit systems like floating microspheres or microballoons. The aim of this article is to review the physiological and anatomical factors and methods for preparing floating microspheres, which plays an important role in design of floating drug delivery systems....
The present study aims to develop and evaluate sustained release matrix type tablets of Ofloxacin, a 4- quinolone derivative with high activity against a wide range of gram positive and gram-negative bacteria. The sustained release matrix type tablets was developed to deliver the drug in systemic circulation at constant level, so a minimum inhibitory concentration of drug is maintained in blood for an extended period of time. Xanthun gum and Guar gum were used as release retardant. Matrix-type tablets were prepared by direct compression technique. Dissolution testing was carried out using USP Apparatus I and the amount of drug released was determined by UV- Spectrophotometer at 294nm. The results showed that tablets from batches F2 and F3 were suitable for sustaining the release of drug from the matrix tablet. The release kinetics studies showed that tablets from batches F2 and F3 showed nearly zero and first order release kinetics respectively. Thus it is concluded that a sustained release formulation for Ofloxacin using Xanthun gum and Guar gum can be prepared....
The aim of present work was to formulate matrix type transdermal drug delivery system of Ondansetron hydrochloride using solvent evaporation technique. HPMC E 50 LV (Hydrophilic) and Eudragit RS 100 (Hydrophobic) were used as polymers in various ratios using glycerin as plasticizer to obtain controlled release of drug. Various physicochemical parameters like thickness, folding endurance, Drug Diffusion, percentage elongation, flatness, moisture content and percentage drug entrapment were studied and desirability function was applied to all the batches. The batch with maximum overall desirability value was selected as optimized batch which gave 56.92 % of drug release in 8 hours and 90.76 % of drug release after 24 hours. In vitro drug release through artificial cellulose membrane follows Higuchi kinetics and showed good correlation between relative concentration of hydrophilic and hydrophobic polymers. The compatibility of drug and polymers was studied by FT-IR and DSC. The results suggested no physicochemical incompatibility between the drug and excipients....
Rapid release tablets are preferred by most physicians because of their ability to attain peak plasma concentration rapidly, by immediately disintegrating in gastric fluid. Pain and inflammation are one of the most common conditions where rapid action of drug is required. Aceclofenac is used for various pain and inflammatory conditions, with fewer side effects than diclofenac. Aceclofenac is completely absorbed after oral administration. There are no immediate release tablets of aceclofenac in market. In order to accomplish that task of the formulation of rapid release tablets and to study the effect of increasing concentrations of super disintegrant, different formulations were prepared with different drug: disintegrants ratio. The various super disintegrants used were indion- 414 , crospovidone, crosscarmellose sodium and sodium starch glycolate. The formulated tablets were evaluated for different characteristics. The different parameters like thickness, friability, hardness, weight variation, drug content were found within limits. Dissolution profile was studied using USP-2 dissolution apparatus. The process of dissolution was studied in 0.1NHCl and Phosphate buffer pH -7.0....
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